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Index > Protein center > Ptprc(Gene name) > Rat
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  • Ptprc (Gene name),
  • Receptor-type tyrosine-protein phosphatase C (Protein name ),  PTPRC_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Ptprc;
    Protein name:
    Receptor-type tyrosine-protein phosphatase C;
    Alternative:
    T200;Leukocyte common antigen(L-CA);
    CD:
    CD45;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Binds GANAB and PRKCSH.
    Function:
    Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Membrane raft Colocalized with DPP4 in membrane rafts.
    Protein Attributes:
    Sequence length:
    1273
    Sequence:
    50:
    MYLWLKLLAF | SLALLGPEVF | VTGQGTTDDG | LDTTEIVLLP | QTDPLPARTT | 
    100:
    EFTPPSISER | GNGSSETTYL | PGFSSTLMPH | LTPQPDSQTP | SARGADTQTL | 
    150:
    SSQADLTTLT | AAPSGETDPP | GVPEESTVPE | TFPGGTPILA | RNSTAPSPTH | 
    200:
    TSNVSTTDIS | SGANLTTPAP | STLGFASNTT | TSTEIATPQT | KPSCDEKFGN | 
    250:
    VTVRYIYDDS | SKNFNANLEG | DKKPKCEYTD | CEKELKNLPE | CSQKNVTLSN | 
    300:
    GSCTPDKIIN | LDVPPGTHNF | NLTNCTPDIE | ANTSICLEWK | IKNKFTCDIQ | 
    350:
    KISYNFRCTP | EMKTFALDKH | GTLWLHNLTV | RTNYTCAAEV | LYNNVILLKQ | 
    400:
    DRRVQTDFGT | PEMLPHVQCK | NSTNSTTLVS | WAEPASKHHG | YILCYKKTPS | 
    450:
    EKCENLANDV | NSFEVKNLRP | YTEYTVSLFA | YVIGRVQRNG | PAKDCNFRTK | 
    500:
    AARPGKVNGM | KTSRASDNSI | NVTCNSPYEI | NGPEARYILE | VKSGGSLVKT | 
    550:
    FNQSTCKFVV | DNLYYSTDYE | FLVYFYNGEY | LGDPEIKPQS | TSYNSKALII | 
    600:
    FLVFLIIVTS | IALLVVLYKI | YDLRKKRSSN | LDEQQELVER | DEEKQLINVD | 
    650:
    PIHSDLLLET | YKRKIADEGR | LFLAEFQSIP | RVFSKFPIKD | ARKSQNQNKN | 
    700:
    RYVDILPYDY | NRVELSEING | DAGSTYINAS | YIDGFKEPRK | YIAAQGPRDE | 
    750:
    TVDDFWKMIW | EQKATVIVMV | TRCEEGNRNK | CAEYWPCMEE | GTRTFRDVVV | 
    800:
    TINDHKRCPD | YIIQKLSIAH | KKEKATGREV | THIQFTSWPD | HGVPEDPHLL | 
    850:
    LKLRRRVNAF | SNFFSGPIVV | HCSAGVGRTG | TYIGIDAMLE | SLEAEGKVDV | 
    900:
    YGYVVNLRRQ | RCLMVQVEAQ | YILIHQALVE | YNQFGETEVN | LSELHSCLQN | 
    950:
    LKKRDPPSDP | SPLEAEYQRL | PSYRSWRTQH | IGNQEENKKK | NRSSNVVPYD | 
    1000:
    FNRVPLKHEL | EMSKESEAES | DESSDEDSDS | EETSKYINAS | FVMSYWKPEM | 
    1050:
    MIAAQGPLKE | TIGDFWQMIF | QRKVKVIVML | TELMSGDQEV | CAQYWGEGKQ | 
    1100:
    TYGDMEVMLK | DTNKSSAYIL | RAFELRHSKR | KEPRTVYQYQ | CTTWKGEELP | 
    1150:
    AEPKDLVTLI | QNIKQKLPKS | GSEGMKYHKH | ASILVHCRDG | SQQTGLFCAL | 
    1200:
    FNLLESAETE | DVVDVFQVVK | SLRKARPGMV | GSFEQYQFLY | DIMASIYPTQ | 
    1250:
    NGQVKKANSQ | DKIEFHNEVD | GAKQDANCVQ | PADPLNKAQE | DSKEVGASEP | 
    1273:
    ASGSEEPEHS | ANGPMSPALT | PSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    E1030h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    E1030m
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    MSDS:
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    96T
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    ELISA Kit for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    E1030r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    U1030m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    U1030h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    U1030r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    P1030Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    P1030Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Receptor-type tyrosine-protein phosphatase C
    Cat.:
    P1030Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Receptor-type tyrosine-protein phosphatase C
    Monoclonal Antibody for Rat Receptor-type tyrosine-protein phosphatase C
    Monoclonal Antibody for Rat Receptor-type tyrosine-protein phosphatase C
    Protein for Rat Receptor-type tyrosine-protein phosphatase C
    Protein for Rat Receptor-type tyrosine-protein phosphatase C
    Protein for Rat Receptor-type tyrosine-protein phosphatase C

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Amgen rat EST program."
      Amgen EST program
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-147 (ISOFORM 4)
    2. 2.
      "Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus."
      Barclay A.N. , Jackson D.I. , Willis A.C. , Williams A.F.
      EMBO J.6:1259-1264(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-218 (ISOFORMS 1; 2; 3 AND 4)
    3. 3.
      Barclay A.N. , Jackson D.I. , Willis A.C. , Williams A.F.
      Submitted (1987-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-1273 (ISOFORMS 1; 3; 4 AND 5)
    4. 4.
      "Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr."
      Thomas M.L. , Barclay A.N. , Gagnon J. , Williams A.F.
      Cell41:83-93(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-1255 (ISOFORM 1)
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